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Microscopy

The next generation of inverted microscope systems has arrived

Olympus' innovative IX3 series of inverted research microscope systems provides effortless, intuitive live cell imaging and clinical analysis. This includes the fully automated IX83 for high-end research applications, the flexible IX73, which can be configured in manual, semi-motorised or motorised modes, and the easy-to-use IX53 with fluorescent capabilities, which is optimised for the routine examination of tissue samples. Built using worldwide customer feedback and designed to meet the needs of a wide range of users, the new systems offer exceptional ease-of-use and unprecedented optical flexibility via a new, customisable light path. New components can be easily slid into the light path using a series of swappable decks. This opens up many new avenues for exploration, allowing researchers to follow their imaginations. The new systems also utilise the latest Olympus innovations in frame design, optics and software, providing exceptional stability, optical quality, accuracy and reliability.

The IX3 inverted microscope systems are optimised for live cell imaging. In particular, the IX73 and IX83 are built using a new swappable deck design, which allows optical modules to be easily and rapidly slipped in and out as needed, including magnification changers, filter turrets, a right side port and more. This means that the systems are truly 'open access' and can be fully customised to meet the requirements of a wide range of applications, even allowing the utilisation of user-designed custom modules to provide the ultimate level of flexibility. This design also allows the systems to grow alongside the evolving demands of your life science research projects. This is especially true of the IX73, which is highly configurable and capable of integrating with a range of computer-coded or motorised components.

The new frame design of the IX3 systems provides an excellent level of mechanical and thermal stability, and includes an ultrasonic motorised stage for quiet, smooth and precise movement. Olympus UIS2 optics deliver sharp, bright images, while the proprietary Olympus fly-eye fluorescence illuminator generates even, vivid illumination across the specimen. This provides a much wider field of view than previously possible, with even illumination that fills the detectors of most cameras, even those with larger chips. IX3 systems are also compatible with the Olympus Real-Time Controller, offering high-precision imaging via microsecond synchronisation for advanced studies using high-speed light sources and triggered cameras.

Optimised for ease-of-use, the IX3 systems also help streamline complex imaging and measurement tasks. The systems integrate seamlessly with the powerful Olympus cellSens imaging software to allow advanced analysis at the click of a button, while the IX83 also offers a touch-panel interface that can be located in the most ergonomic position for each user, providing simple, quick and comfortable operation. With live cell imaging in mind, the IX83 is also compatible with the new Olympus ZDC Z-Drift Compensation system, which automatically ensures that every image you capture is in perfect focus. In particular, the ZDC can work independently of software control, and uniquely combines a one-shot and continuous mode in the same unit, ensuring your system can be easily optimised for a wide range of different applications. 

Built to provide the highest-level of quality, flexibility and reliability, the IX3 series of microscope systems will meet all your research and examination needs, now and in the future.

Open access meets motorisation for
intuitive and flexible life science microscopy

The Oympus IX83 microscope, is the most advanced member of the new IX3 series of inverted imaging systems for life science researchers. The IX83 allows any user to rapidly and effortlessly obtain expert results, without the need for in-depth microscopy knowledge. This includes reliable long-term time-lapse imaging of living cells, as well as high-end fluorescence applications such as total internal reflection fluorescence (TIRF) microscopy. Every component of the light path, from the illuminator to the optics, is dedicated to imaging of the highest quality with minimal loss of light across a range of brightfield, phase contrast and fluorescent illumination options. This also includes an expanded field of view, increasing the amount of your sample you can reliably capture. With a unique 'open access' frame design and touch panel operating system, users can mould the components and controls to best suit their workflow. In this way, the IX83 microscope systems offer a new level of usability and application flexibility for life science research.

Like every member of the innovative new IX3 series of inverted microscopes, the IX83 is designed to adapt to the research needs of every user thanks to an 'open access' frame design that makes it quick and easy to swap components in and out of the light path. These include motorised fluorescence mirror turrets, coded intermediate magnification changers, motorised fast filter wheels, a right-side port with C-mount and more. Better still, for users that share a microscope system, the IX83 can be quickly modified in just a few minutes to fit the needs of each individual user, without the need for complex tools or expertise. This allows every researcher to get the best out of the system, and makes it easy to upgrade in the future as new experimental avenues are opened up and explored.

The fully motorised IX83 offers intuitive and ergonomic fine control over every aspect of microscope performance, with manual and automatic adjustments easily made via either the touch panel or Olympus cellSens software. The IX83 also works seamlessly with the new Olympus ZDC Z-drift compensation system, which employs a near-infrared light to provide instant, automatic focus without damaging cells. Uniquely, the Olympus ZDC unit offers both 'one-shot' and 'continuous' focus modes and can now even be operated stand-alone or by using the Olympus software packages. This makes it ideal for a wide range of applications, as well as flexible operation by multiple users with differing experimental requirements.

The new design of the IX83 provides exceptional stability and minimal drift, ensuring that even the longest time-lapse experiments will generate reliable and accurate results. In combination with the power and flexibility provided by the Olympus cellSens software, users can easily carry out seemingly complex multi-position or multi-well experiments at the click of a few buttons, especially when using the new Olympus 'Well Navigator' Solution module. Utilising Olympus UIS2 infinity-corrected optics and providing a larger, evenly illuminated field of view at the camera port (Field Number 22), users of an IX83 imaging system will be able to generate bright, insightful images across a range of high-end life science research applications.

Inverted microscopy, intuitive as standard

Olympus' IX73 inverted microscope system for life science imaging, is designed with an emphasis on ease-of-use and working efficiency. This makes it ideal for a range of routine and advanced research tasks. As it can be manual or semi-motorised and contains an innovative 'open access' light path, the IX73 can be easily customised to provide future-proof adaptability and highly sophisticated microscopy. Users can build a uniquely flexible system that enables them to produce expert results with minimal training. This extends from brightfield and phase contrast methods, through to fluorescent imaging. In addition, every image produced is of the highest quality, even during long or complex time lapse experiments, thanks to an enhanced new focus mechanism.  All applications take advantage of the IX73's high quality UIS2 optics, stable and reliable frame and seamless cellSens software integration to generate insightful images at every magnification.

The IX73 has been designed to offer the upmost freedom and ease-of-use, with a range of manual or semi-motorized components to meet every need. Furthermore, the IX73 features a novel 'open access' light path that allows the systems to be rapidly modified, including a one-deck system with an ergonomic low stage height, or a two-deck system with additional expansion capabilities. Modules are easy to slide in and out, and include magnification changers, fast filter wheel turrets and more. This means that within minutes, every user can easily set up and customise the system to meet their unique requirements. Where necessary, customisable parts of the microscope are digitally encoded, allowing full synchronisation with the powerful Olympus cellSens software for accurate parameter documentation.

As well as inherent flexibility, the IX73 provides several enhancements to optimise user experience. These include a new manual stage that provides precise and fluid control, making sample positioning at high magnifications an easy task. The frame under the stage has also been cleverly designed, utilising a removable drip tray that helps prevent contamination and simplifies maintenance of the optical system. For high end applications such as rapid time-lapse imaging, the IX73 is compatible with the Olympus Real Time Controller. This automatically coordinates the synchronous action of filter wheels, shutters, light sources and cameras with microsecond timing for ultra-precision data capture. In addition, an extra large field of view (up to FN=22) can be uniformly illuminated at the camera port, making the IX73 ideal for use with cameras with larger chips.

With the new IX73 imaging system from Olympus, it is simple and comfortable to perform a multitude of imaging techniques, from long term time-lapse imaging through to routine research. In addition, a range of additional components, as well as the capacity for a user-defined level of automation, means that the new systems will meet your all life science needs, today and tomorrow.

Cost-effective and reliable inverted microscopy

The IX53 inverted microscope system from Olympus, offers comfort whilst in constant use in the laboratory. Designed from the ground up to be the finest microscope available for routine analysis, the new system combines ergonomic operation with high quality optics in a cost-effective package. Capable of bright-field, phase-contrast and fluorescence imaging, the IX53 offers a wide range of documentation and even research options. In particular, a long working distance condenser makes rapid, frequent Petri dish observations quick and easy, ensuring that the IX53 is the ideal choice for frequent, regular use, from checking cell culture plates through to the rapid screening of clinical samples.

The IX3 series of inverted microscope systems have been designed based on extensive customer feedback to provide unrivalled ease-of-use and application flexibility. In particular, the highly-stable and robust IX53 is ideal for continual use in research and clinical laboratory environments, as it is exceptionally easy-to-use and has an ergonomic, low stage. The stage also utilises a unique plate positioning system for easy sample tracking, in which user-defined position limits can be applied to immobilise the stage and sample. This ensures that the observation position is not inadvertently lost during operations such as reagent application, and makes it possible to transfer 35 mm dishes from the stage to an incubator and back, while still maintaining the correct field of view.

The IX53 frame is built utilising an innovative, novel deck design, so it can be quickly and easily upgraded to facilitate new application capabilities, such as multi-channel fluorescence imaging. The microscope system also integrates seamlessly with Olympus's powerful and intuitive cellSens software, providing hassle-free imaging and documentation.

Focused on usability and reliability, the cost-effective IX53 delivers exceptional performance across a wide range of routine tasks, with the expandability required to accommodate the needs of tomorrow.

For further information, e-mail: microscopy@olympus-europa.com or view website: www.microscopy.olympus.eu 
Refer to page 271   

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