The Journal of Industry and Technology

Industrial Analytical Instrumentation

Euro Technology

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Ultra-high-performance liquid chromatography - mass spectrometry

New high purity grade of solvents
for UHPLC-MS instrumentation

Fisher Chemical Optima UHPLC-MS solvents designed to reduce background signal and increase sensitivity for rapid trace analysis.

New, exceptionally pure mobile phase solvents for ultra-high-performance liquid chromatography-mass spectrometry (UHPLC-MS) instruments have been designed to reduce background signal and minimize chromatographic interferences, facilitating accurate, sensitive and rapid trace analysis.

Fisher Chemical Optima UHPLC-MS solvents are high-quality, ultra-pure and designed to address the trace analysis needs of chromatographers performing state-of-the-art UHPLC. These new solvents are qualified for use with UHPLC/MS instrumentation, such as the Thermo Scientific Vanquish system.

UHPLC-MS is becoming the preferred technique to LC-MS in analytical laboratories, as it enables users to perform separations substantially faster, due to the innovative sub-2 micron columns. Submicron filtration also reduces the clogging of instruments, columns and check valves. A typical LC-MS gradient run can take up to 60 minutes, whereas UHPLC-MS can reduce this to just five minutes, while yielding a similar resolution without compromising flow rates.

Optima UHPLC-MS solvents are ideal for detecting trace amounts of analyte by MS/MS using either gradient or direct-flow analysis without baseline interference. Notably, Optima UHPLC-MS solvents provide a very low mass/noise level in both positive- and negative-mode ionization, minimal metal ion content and a low UHPLC-UV response using photo diode array detection.

"The quality of these high-purity solvents is linked directly to the sensitivity of high-end mass spectrometers, where parts-per-trillion levels of analyte can be detected by the signature product ion peaks, " said Subhra Bhattacharya, senior product development scientist at Thermo Fisher Scientific. "The low signal-to-noise ratio achieved with the Optima UHPLC-MS solvents highlights the ultrahigh purity, resulting in minimal background interference."

Thermo Fisher Scientific Inc. in profile
Thermo Fisher Scientific Inc. is the world leader in serving science, with revenues of $17 billion and approximately 50,000 employees in 50 countries. Thermo Fisher Scientific's mission is to enable its customers to make the world healthier, cleaner and safer, whilst helping their customers accelerate life sciences research, solve complex analytical challenges, improve patient diagnostics and increase laboratory productivity. Through its premier brands - Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific and Unity Lab Services - offer an unmatched combination of innovative technologies, purchasing convenience and comprehensive support.

For further information, view website: www.thermofisher.com 

For further information on the Fisher Chemical Optima UHPLC-MS solvents, view website: www.fishersci.com/fisherchemical 
Refer to page 689

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